Sublingual drug delivery improves bioavailability in paediatric and elderly patients, indicating enhanced treatment options.
Sublingual drug delivery holds promise for facilitating quicker and more direct absorption of medications into the bloodstream. The sublingual area in the mouth enhances drug absorption, bypassing the liver's first-pass metabolism, resulting in higher bioavailability and improved patient compliance. Sublingual medications can help children, the elderly, and individuals with mental health disorders or those that have dysphasia. Over time, these new options help in improving treatment management by making medication easier and more convenient. Because of their potential for emergency treatment, there is a growing demand for sublingual drug delivery. In contrast to the oral cavity's palatal and buccal areas, the sublingual region is more permeable; thus, fast-dissolving sublingual tablets have the potential to significantly outperform existing treatment options for certain patient populations, including elderly and paediatric patients.
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Sharma et al. (2025) studied this question.
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