FIGURE 2 from High-resolution Diffusion-weighted Imaging to Detect Changes in Tumor Size and ADC, and Predict Adverse Biopsy Histology during Prostate Cancer Active Surveillance

Comparing high-resolution MRI and standard MRI. A, Multiparametric prostate MRIs incorporating either S-DWI or HR-DWI were compared. Patients on prostate cancer As were enrolled in a clinical trial and changes in tumor size or ADC as seen on MRI studies approximately 12 months apart were used to predict adverse biopsy histology. B–D, Representative MRIs taken 12 months apart for an AS patient enrolled in the clinical trial. B, T2-TSE, DCE, and DCE (color) images from the second MRI are shown and a prostate lesion is highlighted with arrows. C, S-DWI and HR-DWI images from both timepoints are shown. D, Standard and high-resolution ADC maps from both timepoints are shown. DWI, diffusion-weighted image; ADC, apparent diffusion coefficient; TSE, turbo spin echo; DCE, dynamic contrast enhanced.