Clinical improvement of some indicators of the activity of non-alcoholic fatty liver disease after correction of intestinal dysbiosis with dietary fiber

Relevance. Metabolic disorders in non-alcoholic fatty liver disease play a significant role in the development and progression of cardiovascular diseases, accelerating their occurrence, aggravating their course and outcomes. The occurrence and maintenance of a chronic staged course (from fatty hepatosis and non-alcoholic steatohepatitis to progressive liver fibrosis) of the disease is associated with quantitative and qualitative changes in the composition of the intestinal microflora. At the same time, outpatients may consider themselves healthy, which makes it difficult to implement a comprehensive treatment program. The peculiarities of the combination of clinical, laboratory and microbiological characteristics of patients with hepatic steatosis require detailed study for the earliest identification of therapeutic targets, diagnostic and prognostic tools and their effective correction. Purpose of the study: to determine the clinical, laboratory and microbiological characteristics of patients with non-alcoholic fatty liver disease. Material and methods: clinical, laboratory and microbiological data of outpatients were collected, anthropometric indicators were calculated. Statistical analysis: Microsoft Excel 2010 and StatTech v.3.1.8 (Russia) with assessment for normality of distribution and chi-square test. Differences were assessed by nonparametric analysis at a significance level of p<0.05. Results. Patients were assigned to the observation group if they had NAFLD or to the comparison group in it absence. Many patients in the observation group were found to have metabolic syndrome and/or abdominal obesity, accompanied by asthenic syndrome, functional disorders of the biliary tract, and disorders of lipid and carbohydrate metabolism. In the luminal microflora of the intestines of patients in the observation group, the presence of representatives of Pseudomonas spp. was significantly more often detected. Correction of microbiological disorders by adding dietary fiber to the diet provided clinical improvement. Conclusion. In addition to clinical and laboratory data, microbiological characteristics of patients can be used for the earliest diagnosis and effective correction of disorders that occur during the development of NAFLD.