Evaluating activity of novel STING agonists on alternate STING isoforms. A total of 5 × 10⁴ HEK-Blue reporter cells expressing indicated STING alleles were incubated with 100 µg/mL CDN for 24 hours. IRF3/9 activity was measured by secreted alkaline phosphatase (SEAP) assay. IFNα positive control indicates presence and functionality of the IRF3/9 SEAP reporter in these cells. Statistical significance was calculated using repeated measures one-way ANOVA (n = 2). ns, not significant; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.
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Boda et al. (2024) studied this question.
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