Apurinic Apyrimidinic Endonuclease 1 Gene Polymorphism Association with Total Antioxidant Level in Automobile Technicians

The association of apurinic apyrimidinic endonuclease 1 (APE1) gene polymorphism with total antioxidant level in automobile technicians was proposed in the present study, using APE1 Asp148Glu (rs3136820) variation, reactive oxygen species (ROS) and total antioxidant levels (TAO) were depended in a case-control study, the results showed the mean of age (33.30 ± 1.94) years, body mass index (BMI) (26.19 ± 3.53) kg/m2 and work period (7.68 ± 4.9) years, the ROS level non-significant changes between cases and control (p 0.567) and significant elevation in TAO (p 0.000), The APE1 Asp148Glu (rs3136820) genotyping produced three genotypes (TT, GG and TG). The results of APE1 genotyping distribution showed non-significant association of Asp148Glu (rs3136820) with automobile technicians GG (p 0.8636), GT (p0.0718), also allele frequency didn’t associate with cases (p 0.8434), non-significant association of APE1 genotypes with smoker (p 0.1656), hookah (p 0.1001), alcohol uptake (p 0.8012) and chronic disease (p 0.6981), The ROS levels according to APE1 genotypes show non-significant variation (p 0.976) among genotypes. The TAO level according to APE1 genotypes showed significant differences among GG and TG in control group while significant elevation in TAO between TG genotypes in cases and control groups. The current study concluded that the APE1 gene polymorphism APE1 Asp148Glu didn’t associate with automobile technicians with long exposure to lead and cadmium, but it was associated with elevation in TAO level in workers