Key result
Vascular and endovascular interventions in patients with abdominal aortic diseases were associated with elevated antioxidant parameters that prevented oxidative damage postoperatively.
Why the study?
The study aimed to determine genetic polymorphisms of antioxidant enzymes, oxidative stress, and the antioxidant enzyme response during vascular and endovascular interventions for infrarenal abdominal aorta diseases.
How do vascular and endovascular interventions affect oxidative stress and antioxidant enzyme activity in current or ex-smokers with diseases of the infrarenal abdominal aorta?
Observational (n=24)
How do vascular and endovascular interventions affect oxidative stress and antioxidant enzyme activity in current or ex-smokers with diseases of the infrarenal abdominal aorta?
Vascular and endovascular interventions for abdominal aortic diseases in smokers are associated with changes in oxidative stress and antioxidant enzyme activity.
Should not yet change practice for aortic interventions in smokers; leaves open whether antioxidant responses improve outcomes.
Introduction: The aim of this study was to determine the genetic polymorphisms of some antioxidant enzymes together with oxidative stress and the response of some antioxidant enzymes against this situation in vascular and endovascular interventions performed for diseases of the infrarenal abdominal aorta. Material and methods: Twenty-four current or ex-smoker patients (eight aortoiliac occlusive disease (AOD), 16 abdominal aortic aneurysm (AAA)) who were operated were included in this pilot study. Malonyl dialdehyde (MDA) levels, as an indicator of oxidative stress, reduced glutathione, catalase and superoxide dismutase enzymes, which are indicators of antioxidant status, which were measured in aortofemoral bypass in AODs, and in endovascular abdominal aortic aneurysms repairs in the preoperative, operative, and postoperative periods. Genetic polymorphisms of these antioxidant enzymes developing a response to the damage in the preoperative blood samples were determined by using the PCR-RFLP method. Results: = 0.63) in the oxidative damage in the operative and postoperative periods compared to the preoperative period prevented the damage and was thought to be associated with the elevation of some effective antioxidant parameters in the operative and postoperative periods. Conclusions: > 0.05).
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Türker et al. (2019) conducted an observational in Tobacco related diseases of abdominal aorta (AOD, AAA) (n=24). Vascular and endovascular interventions vs. Preoperative baseline was evaluated on Oxidative stress and antioxidant status. Vascular and endovascular interventions in patients with abdominal aortic diseases were associated with elevated antioxidant parameters that prevented oxidative damage postoperatively.
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