Key result
Abdominal aortic aneurysms are linked to higher serum total oxidant status and oxidative stress index.
Why the study?
The oxidant-antioxidant balance in patients with abdominal aortic aneurysms was not well characterized.
Are systemic oxidant and antioxidant balance markers altered in patients with abdominal aortic aneurysms compared to controls?
Case-Control (n=88)
Are systemic oxidant and antioxidant balance markers altered in patients with abdominal aortic aneurysms compared to controls?
p-value: p=<0.001
Systemic oxidative imbalance, driven by increased total oxidant status, is significantly associated with abdominal aortic aneurysms and correlates with aortic diameter.
The aim of this study was to evaluate the oxidant-antioxidant balance in patients with abdominal aortic aneurysms (AAA). Forty-two consecutive patients with AAA and 46 control subjects were included. Total oxidant status (TOS) and total antioxidant status (TAS) levels were measured and the oxidative stress index (OSI) value determined. Serum TOS and OSI values in patients with AAA were higher than those in the controls (p < 0.001, p < 0.001, respectively). There was a positive correlation between abdominal aortic diameters, serum TOS levels (r = 0.592, p < 0.001) and OSI values (r = 0.598, p < 0.001). A cut-off value of 17.68 µmol H₂O₂equivalent/L for TOS was associated with 86% sensitivity and 83% specificity and a cut-off value of 1.77 for OSI was associated with 86% sensitivity and 81% specificity for predicting AAA. Systemic oxidative imbalance develops in patients with AAA, particularly as a result of an increase in TOS.
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Menteşe et al. (2015) conducted a case-control in Abdominal aortic aneurysm (n=88). Abdominal aortic aneurysm vs. Control subjects was evaluated on Serum total oxidant status (TOS) and oxidative stress index (OSI) (p=<0.001). Patients with abdominal aortic aneurysms had significantly higher serum total oxidant status and oxidative stress index values compared to controls (p < 0.001).
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