Key result
AAA linked to higher aortic tissue Fe, Cu, and TBARS versus aortic occlusive disease.
Why the study?
The relationship between atheromatous disease and degenerative aneurysm remains undefined, necessitating comparison of trace element levels in abdominal aortic aneurysm and aortic occlusive disease.
Are tissue levels of Fe, Cu, Zn, and TBARS different in patients with abdominal aortic aneurysm compared to those with aortic occlusive disease?
Comparison
Tissue Fe, Cu, Zn, and TBARS levels in AAA vs AOD patients
Design
Prospective clinical observational study at an institutional referral center
Authors
Loading...
Suggests oxidative stress involvement in AAA; hypothesis-generating and should not yet change practice.
Observational (n=80)
No
Are tissue levels of Fe, Cu, Zn, and TBARS different in patients with abdominal aortic aneurysm compared to those with aortic occlusive disease?
p-value: p=<0.001
Higher levels of iron, copper, and oxidative stress markers in abdominal aortic aneurysms compared to occlusive disease suggest a potential role for trace element imbalance in aneurysm formation.
Köksal et al. (2007) conducted an observational in Abdominal aortic aneurysm or aortic occlusive disease (n=80). Abdominal aortic aneurysm (AAA) vs. Aortic occlusive disease (AOD) was evaluated on Tissue Fe, Cu, Zn, and TBARS levels in the abdominal aorta (p=<0.001). Patients with abdominal aortic aneurysm had significantly higher aortic tissue levels of Fe, Cu, and TBARS compared to those with aortic occlusive disease (p<0.001 for each).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: