Key result
Endovascular repair of abdominal aortic aneurysms was associated with higher oxidative stress index (P=0.004 at 1h) but lower total oxidative stress at 24 hours (P=0.018) compared to open repair.
Why the study?
Does endovascular repair compared to open repair reduce perioperative oxidative stress in patients with abdominal aortic aneurysm?
Cohort (n=20)
Does endovascular repair compared to open repair reduce perioperative oxidative stress in patients with abdominal aortic aneurysm?
p-value: p=0.004
Endovascular repair of abdominal aortic aneurysms may be associated with lower perioperative oxidative stress compared to open repair.
May support lower late perioperative oxidative stress with endovascular repair; hypothesis-generating and requires randomized confirmation before practice change.
BACKGROUND/AIM: To investigate the differences in perioperative oxidative stress (OS) in abdominal aortic aneurysm (AAA) patients treated with either endovascular repair (EVAR) or open repair (OR). MATERIALS AND METHODS: Twenty patients (11 OR, 9 EVAR) treated for AAA with no known malignant or inflammatory disease and an aneurysm diameter of over 5 cm and no rupture were included in the study. Blood samples were obtained preoperatively, during aortic occlusion, and 1 h and 24 h after reperfusion. Total antioxidant status (TAS), total oxidative stress (TOS), and malondialdehyde (MDA) levels were measured and oxidative stress index (OSI) was calculated. RESULTS: OSI at 1 h and 24 h after reperfusion was higher in the EVAR group (P = 0.004 and P = 0.002, respectively). TAS levels were higher (P = 0.001, P = 0,029). MDA levels showed no difference (P = 0.291, P = 0.076). TOS levels were lower 24 h after reperfusion in the EVAR group (P = 0.018). CONCLUSION: Markers of oxidative stress were lower in the EVAR group. This may be associated with advantages of EVAR. More studies are required for a clear-cut conclusion.
No takes yet. Share an insight, caveat, or question.
Doğan et al. (2015) conducted a cohort in Abdominal aortic aneurysm (n=20). Endovascular repair (EVAR) vs. Open repair (OR) was evaluated on Perioperative oxidative stress (OSI, TAS, TOS, and MDA levels) (p=0.004). Endovascular repair of abdominal aortic aneurysms was associated with higher oxidative stress index (P=0.004 at 1h) but lower total oxidative stress at 24 hours (P=0.018) compared to open repair.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: