Key result
Cytokine gene polymorphisms did not affect the overall magnitude of the cytokine response to elective AAA repair, despite a higher IL-10 response in patients with an IL-10 - 1082 A allele (P=0.030).
Why the study?
Do cytokine gene polymorphisms affect in vivo cytokine production in patients undergoing elective abdominal aortic aneurysm repair?
Observational (n=100)
Do cytokine gene polymorphisms affect in vivo cytokine production in patients undergoing elective abdominal aortic aneurysm repair?
p-value: p=0.030
While specific IL-10 polymorphisms affect the IL-10 response to AAA repair, the overall magnitude of the cytokine response does not appear to be significantly altered by individual patient cytokine gene polymorphisms.
Gene polymorphisms should not guide perioperative management in elective AAA repair; hypothesis-generating for targeted IL-10 allele effects.
BACKGROUND: Cytokines are key mediators of the inflammatory response to surgery and polymorphic sites in their genes have been shown to affect cytokine production in vitro. The aim of this study was to determine whether cytokine gene polymorphisms affect cytokine production in vivo in patients undergoing abdominal aortic aneurysm (AAA) repair. METHODS: One hundred patients admitted for elective AAA repair had plasma levels of interleukin (IL) 1beta, IL-6, IL-10 and tumour necrosis factor (TNF) alpha measured at induction of anaesthesia and 24 h after operation. Genotypes for each patient were determined using induced heteroduplex genotyping for the following loci: IL-1beta + 3953, IL-6 - 174, IL-10 - 1082/-592 and TNF-alpha - 308. RESULTS: Patients with an IL-10 - 1082 A allele had a significantly higher IL-10 response to surgery than those without an A allele (P = 0.030) and there was also a significant difference in IL-10 response between patients with IL-10 - 1082 AA genotypes and those with GG genotypes (P = 0.030). CONCLUSION: Elective AAA repair results in a measurable cytokine response. In this study the magnitude of this response was not affected by the individual patient's cytokine gene polymorphisms.
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Bown et al. (2003) conducted an observational in abdominal aortic aneurysm (AAA) (n=100). Cytokine gene polymorphisms vs. Alternative genotypes was evaluated on Plasma levels of IL-1beta, IL-6, IL-10 and TNF-alpha (p=0.030). Cytokine gene polymorphisms did not affect the overall magnitude of the cytokine response to elective AAA repair, despite a higher IL-10 response in patients with an IL-10 - 1082 A allele (P=0.030).
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