Key result
In patients with small abdominal aortic aneurysms, the IL-6 -174 GG genotype was associated with lower cardiovascular mortality compared to GC and CC genotypes (HR 0.32; 95% CI 0.12-0.93; P=0.036).
Why the study?
Abdominal aortic aneurysm involves inflammation with increased circulating IL-6, but the relationship between IL-6, its genotype, and aneurysm prognosis is unclear.
Does the -174 G-->C IL-6 genotype predict aneurysm growth and survival in patients with abdominal aortic aneurysms?
Observational (n=485)
Does the -174 G-->C IL-6 genotype predict aneurysm growth and survival in patients with abdominal aortic aneurysms?
In patients with small abdominal aortic aneurysms, the -174 G-->C IL-6 genotype predicts future cardiovascular mortality, with the GG genotype associated with lower mortality.
BACKGROUND: Abdominal aortic aneurysm is a multifactorial disorder in which inflammation is an important pathophysiological feature. In explant culture, aneurysm biopsies secrete large amounts of interleukin-6 (IL-6), and among aneurysm patients, the circulating concentration of IL-6 appears to be increased. METHODS AND RESULTS: We investigated, in 19 patients, whether aneurysm wall was an important source of circulating IL-6. We also tested the hypotheses, in 466 patients with a small aneurysm, that (1) high concentrations of circulating IL-6 signaled rapid aneurysm growth and (2) the -174 G-->C polymorphism in the IL-6 promoter predicted survival. For 19 patients with large or inflammatory aneurysms, the concentration of IL-6 was higher in the iliac arteries than the brachial arteries (median difference 26.5 pg/mL, this difference increasing with aneurysm diameter, P=0.01). In 466 patients with small aneurysms, the frequency of the -174 C allele (0.40) was similar to that in a normal healthy population. Patients of GG genotype had lower plasma concentrations of IL-6 than patients of GC and CC genotypes (medians 1.9, 4.8, and 15.6 pg/mL, respectively, Kruskal-Wallis P=0.047). Cardiovascular and all-cause mortalities were lower for patients of GG genotype than for patients of GC and CC genotype: hazard ratios 0.32 (95% CI 0.12 to 0.93), P=0.036, and 0.51 (95% CI 0.25 to 1.00), P=0.05, respectively. There was no association between plasma IL-6 or IL-6 genotype and aneurysm growth. CONCLUSIONS: Aortic aneurysms appear to be an important source of circulating IL-6, the concentration being influenced by genotype. For patients with small aneurysms, the -174 G-->C IL-6 genotype predicts future cardiovascular mortality.
No takes yet. Share an insight, caveat, or question.
Jones et al. (2001) conducted an observational in Abdominal aortic aneurysm (n=485). IL-6 -174 GG genotype vs. IL-6 -174 GC and CC genotypes was evaluated on Cardiovascular mortality (HR 0.32, 95% CI 0.12-0.93, p=0.036). In patients with small abdominal aortic aneurysms, the IL-6 -174 GG genotype was associated with lower cardiovascular mortality compared to GC and CC genotypes (HR 0.32; 95% CI 0.12-0.93; P=0.036).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: