Key result
The GG genotype of the IL-6 rs1800796 polymorphism, smoking, and hypertension were independently associated with an elevated risk of abdominal aortic aneurysm.
Why the study?
Recent studies have investigated the link between the IL-6 rs1800796 polymorphism and abdominal aortic aneurysm risk, but no Chinese studies had addressed this association.
Is the IL-6 rs1800796 polymorphism associated with an increased risk of abdominal aortic aneurysm in a Chinese Han population?
Case-Control (n=358)
Is the IL-6 rs1800796 polymorphism associated with an increased risk of abdominal aortic aneurysm in a Chinese Han population?
The IL-6 rs1800796 polymorphism (GG genotype), smoking, and hypertension are independent risk factors for abdominal aortic aneurysm in the Chinese Han population.
Background: Recent researches have investigated the link between the rs1800796 polymorphism (− 572G/C) in the interleukin-6 (IL-6) gene and the risk of abdominal aortic aneurysm (AAA). However, no Chinese studies have addressed the association between the risk of AAA and this polymorphism. Methods: This case-control study included 153 AAA patients and 205 controls. Diabetes mellitus, hypertension, dyslipidemia, and coronary artery disease (CAD) status were collected. The AAA and control groups were 69.20 ± 7.56 and 68.50 ± 7.12 years old, respectively. Results: The analysis revealed that the G allele and GG genotype of the IL-6 rs1800796 polymorphism were remarkedly correlated with an elevated risk of AAA. The GG genotype displayed an association with the risk of AAA after adjustment for gender, body mass index, age, drinking, and smoking. Subgroup analyses indicated that this polymorphism elevated the risk of AAA among males, individuals aged ≥ 70 years, smokers, drinkers, individuals with a body mass index (BMI) ≥ 25 kg/m 2 , patients without diabetes, and patients with hypertension. Univariate and multivariate analyses indicated that smoking, hypertension, and the GG genotype (rs1800796 polymorphism) were independently related with the risk of AAA. Conclusion: The IL-6 rs1800796 polymorphism increases the risk of AAA. In addition, smoking, hypertension, and the GG genotype of the rs1800796 polymorphism are independent risk factors for AAA. Further studies of Chinese populations are needed to validate these findings.
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Zhang et al. (2021) conducted a case-control in abdominal aortic aneurysm (n=358). IL-6 rs1800796 polymorphism (GG genotype) vs. Controls without the GG genotype was evaluated on Risk of abdominal aortic aneurysm. The GG genotype of the IL-6 rs1800796 polymorphism, smoking, and hypertension were independently associated with an elevated risk of abdominal aortic aneurysm.
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