Key result
The -174 C allele of the IL-6 gene was associated with an increased risk of myocardial infarction in older men (OR 2.886; 95% CI 1.801-4.624; P=0.0001).
Why the study?
Does the -174 C allele polymorphism in the IL-6 gene increase the risk of myocardial infarction in men?
Case-Control (n=457)
Does the -174 C allele polymorphism in the IL-6 gene increase the risk of myocardial infarction in men?
Odds Ratio: 2.886 (95% CI 1.801–4.624)
p-value: p=0.0001
The -174 C allele of the IL-6 gene promoter polymorphism is an age-dependent risk factor for myocardial infarction in older men and is associated with higher IL-6 plasma levels.
Should not yet alter MI risk assessment in older men; leaves open IL-6 genotyping utility in prospective risk models.
Several studies show that inflammatory components may contribute to atherosclerosis and increase the risk for myocardial infarction (MI). Interleukin-6 (IL-6) is a key pro-inflammatory and immune-modulatory cytokine of relevance for cardiovascular diseases. In this case-control study, 200 patients with MI and 257 healthy controls were genotyped for the polymorphism present in -174 promoter region of the IL-6 gene. Plasma concentrations of IL-6 and C-reactive protein (CRP) in a group of patients and controls were measured. The -174 C allele was associated with an increased risk of developing MI (OR = 2.886, c.i. = 1.801-4.624, P = 0.0001) in older patients, while no association was found in younger ones. The IL-6 plasma levels were higher in patients with MI carrying the CC genotype than in GG patients (CC carriers, IL-6 = 2.97 pg mL(-1) vs. GG carriers = 1.81 pg mL(-1), P = 0.016). A positive correlation of IL-6 levels with those of CRP in serum from patients with MI was also found. Data from this study suggest that the C allele of the promoter polymorphism in the IL-6 gene is a risk factor for MI in the elderly, and the production of the IL-6 is differentially affected by different genotypes of the IL-6 -174 promoter polymorphism.
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Chiappelli et al. (2005) conducted a case-control in Myocardial infarction (n=457). -174 C allele of the IL-6 gene vs. Healthy controls / non-carriers was evaluated on Risk of developing myocardial infarction in older patients (OR 2.886, 95% CI 1.801-4.624, p=0.0001). The -174 C allele of the IL-6 gene was associated with an increased risk of myocardial infarction in older men (OR 2.886; 95% CI 1.801-4.624; P=0.0001).
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