Pharmacokinetic Study of Aloin Nanoparticulate: Enhanced Oral Formulation Bioavailability

This research aimed to prepare and assess an aloin nanoparticle that might increase its oral bioavailability. Utilizing the nanoprecipitation process, aloin Poly lactic-co-glycolic acid (PLGA) nanoparticulate was formulated and studied for the best strategy based on their characteristics and in-vitro release. The aloin nanoparticle stability research was evaluated at room temperature for a duration of three months. Additionally, pharmacokinetic (PK) tests were analyzed by using various parameters and experiments done by taking female wistar albino rats, with weights of approximately (150–200 gm). The animal was appropriately given the proper housing according to the protocol and placed in a period of twelve hours day and night. The drug was administered for 72 hours at a dosage of 10 mg/kg. of all the aloin nanoformulations developed, the one with the best size of particles was 98.5 nm with an entanglement efficacy of 98.09%. The results show that when compared to pure aloin, aloin PLGA nanoparticulate has a higher bioavailability.