Evaluation of Polyherbal Formulation for Antihyperlipidemic Activity

Hyperlipidemia, characterized by elevated plasma concentrations of lipids and lipoproteins, emerged as a decisive menace for cardiovascular disorders. Imminent side effects linked to synthetic drugs; there is a growing interest in exploring herbal remedies for managing hyperlipidemia. This study delves into examining the antihyperlipidemic effects of a polyherbal formulation composed of extracts from Ailanthus excelsa Roxb (leaves and stems), Cymbopogon citratus (leaves), and Allium sativum (bulbs). The PHF was orally administered at 200 and 400 mg/kg doses. Results revealed a noteworthy reduction in serum and liver biochemical parameters in hyperlipidemic rats treated with PHF. Additionally, the extract demonstrated a noteworthy decrease in the action of HMG-CoA reductase, indicating a potential mechanism for its antihyperlipidemic activity. To sum up, PHF administered at doses of 200 and 400 mg/kg exhibited effective antihyperlipidemic activity in both animal models. The observed inhibition of HMG-CoA reductase enzyme pathway suggests a plausible mechanism of action for the extract’s therapeutic effects. These findings contribute to the expanding body of evidence supporting the clinical relevance of herbal drugs in hyperlipidemia treatment, offering a potential avenue for developing alternative and safer therapeutic interventions for cardiovascular health.