The Role of Curcumin and Neem in the Form of Mouthwash in the Treatment of Aphthous Ulcer in the Oral Cavity

Background: Aphthous ulcers are common painful lesions that affect the oral mucosa. Traditional treatments often include topical agents to reduce inflammation and promote healing. Curcumin and neem are two natural compounds with known anti-inflammatory and antimicrobial properties, which may offer therapeutic benefits in the treatment of aphthous ulcers. Materials and Methods: Aphthous ulcers were the target of this research, which sought to determine if a mouthwash containing curcumin and neem was effective in treating them. About 100 people with aphthous ulcers were part in a randomized controlled experiment. Participants were divided into two groups: one receiving the curcumin and neem mouthwash and the other receiving a placebo mouthwash. Treatment was administered twice daily for two weeks. Pain scores, ulcer size, and healing time were recorded at baseline and throughout the study period. Results: When compared to the placebo group, the group that received the mouthwash containing curcumin and neem showed a substantial decrease in pain levels (p < 0.05). In the treatment group, the size of the ulcer reduced by 50%, whereas in the control group, it fell by 20% (p < 0.01). Ulcers in the treatment group healed an average of seven days faster than in the control group, which took twelve days. Conclusion: According to the results of this research, a mouthwash that contains curcumin and neem might help alleviate discomfort, speed up the healing process, and ultimately speed up the treatment of oral aphthous ulcers. We need more studies to figure out what’s going on and how to make the best treatments.