The hydroalcoholic concentrate and its fractions of Punica granatum L. leaves were tested for antilithiatic activity. The evaluation includes in-vitro as well as in-vivo investigations. The extract and its fractions were tested in-vitro for their effects on urolithiasis-related processes such crystal formation, growth, & aggregation inhibition. In-vivo testing examined stone formation, growth, & dissolution in animal models with artificial urolithiasis after providing the extract and fractions. In-vitro, the hydroalcoholic extract & its components prevented crystal development, aggregation, and formation. These data imply that the extract & fractions may inhibit early stone growth, preventing urolithiasis. In animal models with artificial urolithiasis, the extract and fractions dramatically decreased stone load, with dichloromethane showing better antilithiatic effects. In addition, the therapy helped dissolve and pass stones. These findings demonstrate P. granatum L. leaves’ powerful antilithiatic capabilities, supporting their use in urolithiasis.
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Arra et al. (2024) studied this question.
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