Amplification of Aqueous Solubility of Progesterone Using Melt-Granulation Technique

The objective of the present research was to enhance the rate of dissolution of progesterone by boosting the hormone’s solubility in water. This research determines whether or not employing melt granulation techniques with various polymers may improve the degree to which progesterone is soluble. When looking into the interactions between drug carriers and other substances, researchers turned to techniques such as X-ray diffraction (XRD), differential scanning calorimetry (DSC), and Fourier transform infrared (FTIR). PEG 6000 (1:1.5) demonstrated the highest solubility, followed by PEG 6000 (1:1) > Gelucire 50/13 (1:1.5) > Gelucire 50/13 (1:1). Increasing the solubility of the weakly soluble progesterone was demonstrated by these findings. Melt granulation on polymers boosted progesterone’s dissolution rate, which in turn can raise oral bioavailability.