March 22, 2024Cancer Research

Spatial Transcriptomic Profiling of Cancer-Associated Fibroblasts in Lung Adenocarcinoma With...

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Lung adenocarcinoma with interstitial pneumonia exhibits elevated cytokine signaling and reduced extracellular matrix receptor interactions in cancer-associated fibroblasts.
Spatial transcriptomic profiling revealed 151 differentially expressed genes in alpha-sma-positive stroma, including elevated CXCL8 and NFKB2 compared to cancer without pneumonia.
GeoMx whole-transcriptome atlas analysis across 6 lung adenocarcinoma cases highlights that inflammatory pathways predominate over extracellular matrix cues in fibrotic tumors.

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Implication

Spatial profiling reveals distinct fibroblast expression patterns in lung adenocarcinoma with interstitial pneumonia, suggesting inflammatory signaling drives stroma-cancer interactions.

Cite This Study

Inoue et al. (2024) studied this question.

synapsesocial.com/papers/68e72ce5b6db6435876a6d1f https://doi.org/10.1158/1538-7445.am2024-5484

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Implication

Spatial profiling reveals distinct fibroblast expression patterns in lung adenocarcinoma with interstitial pneumonia, suggesting inflammatory signaling drives stroma-cancer interactions.

Spatial Transcriptomic Profiling of Cancer-Associated Fibroblasts in Lung Adenocarcinoma With...

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Implication

Cite This Study

Spatial Transcriptomic Profiling of Cancer-Associated Fibroblasts in Lung Adenocarcinoma With...

Key Points

Discussion

Implication

Cite This Study

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