March 22, 2024Cancer Research

Engineered Bacteria Surface-Displaying Cytokines for Enhanced Tumor Immunotherapy

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Authors

SYShaobo YangNortheastern University MSMichal ShefferDana-Farber Cancer Institute IKIsabel KaplanDana-Farber Cancer Institute

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Implication

Preclinical study demonstrates that cytokine-displaying bacteria boost CAR-NK cell antitumor efficacy in murine tumor models, indicating a viable strategy for solid tumor immunotherapy.

Key Points

Engineered nonpathogenic bacteria displaying decoy-resistant IL-18 eradicated tumors in 50% of MC38 and 30% of B16F10 mouse models, establishing durable antitumor memory.
In vitro killing assays and syngeneic mouse tumor models evaluated bacterial surface delivery of cytokines alongside mesothelin-directed CAR-NK cell adoptive therapy.
Targeted bacterial cytokine delivery remodels the immunosuppressive tumor microenvironment to enhance effector immunity; mouse model—further preclinical work is required.

Cite This Study

Yang et al. (2024) studied this question.

synapsesocial.com/papers/68e72ceab6db6435876a703a https://doi.org/10.1158/1538-7445.am2024-3608

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Implication

Preclinical study demonstrates that cytokine-displaying bacteria boost CAR-NK cell antitumor efficacy in murine tumor models, indicating a viable strategy for solid tumor immunotherapy.

Engineered Bacteria Surface-Displaying Cytokines for Enhanced Tumor Immunotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Engineered Bacteria Surface-Displaying Cytokines for Enhanced Tumor Immunotherapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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