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March 22, 2024Cancer Research

Abstract 5877: Disulfiram and its metal complexes reversed hypoxia induced stemness and synergized with first line drugs in primary patient derived pancreatic ductal adenocarcinoma cells

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Authors

BSBenjamin J. SmallONOgechi NkeonyeVKVinodh Kannappan

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Small et al. (2024) studied this question.

synapsesocial.com/papers/68e72e24b6db6435876a769chttps://doi.org/10.1158/1538-7445.am2024-5877
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 5738: Repurposing disulfiram for cancer: A drug delivery and population-based approach2024
  2. 2Abstract C025: Enhanced efficacy of gemcitabine analogs and AZD 1775 combination therapy in patient-derived organoids2024
  3. 3Abstract 3167: Impact of gemcitabine modification on redox-driven responses in pancreatic cancer organoids cultured in distinct 3D microenvironments2024
  4. 4Abstract 1258: Harnessing combinatorial nanomedicine for simultaneous BRD4 degradation and stromal disruption against pancreatic ductal adenocarcinoma.2026
  5. 5Abstract LB022: Cutting-edge, drug-free targeted cancer therapeutic: Smart folate-conjugated copolymer intrinsically disables the YAP/TAZ-HIPPO oncoproteins and abrogates pancreatic cancer progression and metastasis2026