Biomarkers of Sensitivity to PCNA Inhibitor AOH1996 Identified via CRISPRi Screening

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A novel cancer-associated PCNA inhibitor selectively kills malignant cells by disrupting the resolution of transcription-replication conflicts.
CRISPR interference screening under 250 nM AOH1996 across 14 generations identified depleted genes linked to DNA repair and cell cycle pathways.
Identified sensitivity biomarkers include targets of known chemotherapies; preclinical cell model requires ongoing clinical trial validation.

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In vitro screening reveals genetic biomarkers linked to AOH1996 sensitivity in cancer cells, highlighting candidates for combination therapy.

Gu et al. (2024) studied this question.

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In vitro screening reveals genetic biomarkers linked to AOH1996 sensitivity in cancer cells, highlighting candidates for combination therapy.