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March 22, 2024Cancer Research

Abstract 2671: Sustained inhibition of CSF1R signaling effectively augments antitumor immune responses through inhibiting tumor-associated macrophages

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Authors

TSTakahiko SatoNagoya UniversityDSDaisuke SugiyamaNagoya UniversityYKYasuhiro KojimaTokyo Medical and Dental University

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Cite This Study

Sato et al. (2024) studied this question.

synapsesocial.com/papers/68e72e34b6db6435876a7c3dhttps://doi.org/10.1158/1538-7445.am2024-2671
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+T cells2013 · 387 citations
  2. 2CSF1R inhibition reprograms tumor-associated macrophages to potentiate anti-PD-1 therapy efficacy against colorectal cancer2024 · 87 citations
  3. 3Abstract 3917: A CXCR4 partial agonist TFF2-MSA improves anti-PD-1 immunotherapy in advanced gastric cancer by selectively targeting PMN-MDSC2024
  4. 4Abstract 2908: SR-A antagonism remodels the myeloid population of tumor immune microenvironment, expands CD8-positive T cells, and enhances antitumor efficacy in vivo2026
  5. 5Abstract 6857: Evolution of myeloid-mediated mechanisms of immunotherapy resistance at single-cell resolution with prostate cancer progression2024