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March 22, 2024Cancer Research

Abstract 663: Irreversible covalent azetidine-based small molecule inhibitors of Stat3 activity block growth of human pancreatic tumors

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Authors

YCYue ChenCedars-Sinai Medical CenterNZNing ZhaiCedars-Sinai Medical CenterPYPeibin YueCedars-Sinai Medical Center

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Chen et al. (2024) studied this question.

synapsesocial.com/papers/68e72e37b6db6435876a7e86https://doi.org/10.1158/1538-7445.am2024-663
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 4563: Small molecules inhibited dysregulated STAT3-proinflammatory axis and induced antitumor responses in pancreatic and breast cancer2026
  2. 2Discovery of the Highly Selective and Potent STAT3 Inhibitor for Pancreatic Cancer Treatment2024 · 41 citations
  3. 3Abstract 3881: Discovery of highly potent, selective and efficacious STAT3 PROTAC degraders capable of achieving long-lasting tumor regression2024 · 1 citations
  4. 4Abstract 4519: Discovery of highly potent, selective and efficacious STAT3 PROTAC degraders capable of achieving complete tumor regression2024
  5. 5Abstract 4509: Discovery of potent and highly efficacious STAT3 PROTAC degraders capable of achieving long-lasting tumor regression2024