March 22, 2024Cancer Research

Single-Cell Multi-Omics Predicts Clinical Outcomes in CD19 CAR T Cell Therapy

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Authors

RLRaymond H. Y. LouieHong Kong University of Science and Technology JSJerome SamirThe University of Sydney CCCurtis CaiKarolinska Institutet

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Implication

Single-cell multi-omics analysis reveals shared CD8+ T cell differentiation trajectories in B-cell malignancies, suggesting non-CAR signals drive immune recovery and clinical outcomes.

Key Points

Both CAR-positive and CAR-negative CD8+ T cells share a common differentiation trajectory terminating in an NK-like state linked to patient clinical outcomes.
Across 115,000 single cells, an emerging 2B4- CD11b+ CD8+ phenotype correlated with complete remission or progressive disease at three and six months post-infusion.
Single-cell multi-omics analysis reveals phenotypic plasticity across longitudinal cohorts, highlighting that non-CAR signals may drive host immune reconstitution.

Cite This Study

Louie et al. (2024) studied this question.

synapsesocial.com/papers/68e72e40b6db6435876a8374 https://doi.org/10.1158/1538-7445.am2024-882

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Implication

Single-cell multi-omics analysis reveals shared CD8+ T cell differentiation trajectories in B-cell malignancies, suggesting non-CAR signals drive immune recovery and clinical outcomes.

Single-Cell Multi-Omics Predicts Clinical Outcomes in CD19 CAR T Cell Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Single-Cell Multi-Omics Predicts Clinical Outcomes in CD19 CAR T Cell Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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