srahunter: A User-Friendly Tool for Efficient Retrieval and Management of SRA Data

Easy access and use of vast datasets are paramount for advancing scientific discovery in steadily expanding studies based on high-throughput sequencing (HTS). The Sequence Read Archive (SRA) is a publicly accessible repository currently holding a huge amount of HTS reads, as part of the International Nucleotide Sequence Database Collaboration (INSDC). However, accessing, downloading, and managing data and metadata efficiently can be challenging. Here, we introduce srahunter , a tool designed to simplify data and metadata acquisition from SRA. Developed with Python, srahunter leverages the core functionalities of SRA Toolkit and Entrez Direct , to enable automated downloading, smart data management, and user-friendly metadata integration through an interactive HTML table https://github.com/GitEnricoNeko/srahunter . Compared to existing tools, srahunter increases the efficiency of metadata retrieval by reducing the technical barriers to SRA data and streamlining the handling of SRA datasets, and can therefore accelerate the development of genomics and multiple ‘omics research.