⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

March 21, 2024Open Access

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

View Full Paper

Ask AI

Bookmark

Share

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Abstract

Biallelic loss of cyclin-dependent kinase 12 (

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Tien et al. (2024) studied this question.

synapsesocial.com/papers/68e73097b6db6435876aa352 https://doi.org/10.1101/2024.03.20.585990

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK132024 · 41 citations
2Abstract PR010: CDK12 loss promotes prostate cancer development while exposing vulnerabilities to paralog-based synthetic lethality2024
3Dual Inhibition of PARP and ATR Induces Synthetic Lethal Vulnerability in Prostate Cancer with CDK12 DeficiencyOriginal Research · 2026 · 1 citations
4Abstract B069: Understanding tumorigenesis and identifying therapeutic targets in CDK12-mutant prostate cancerClinical Trial · 2026
5Synthetic Lethal Targeting of CDK12-Deficient Prostate Cancer with PARP Inhibitors2024 · 23 citations