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March 21, 2024Journal of Clinical MicrobiologyOpen Access

A novel hybridization capture method for direct whole genome sequencing of clinical specimens to inform Legionnaires’ disease investigations

Phillip Weeber Navjot Singh Pascal Lapierre Lisa Mingle Danielle Wroblewski Elizabeth Nazarian Wolfgang Haas Don Weiss Kimberlee A. Musser

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Abstract

The unprecedented precision and resolution of whole genome sequencing (WGS) can provide definitive identification of infectious agents for epidemiological outbreak tracking. WGS approaches, however, are frequently impeded by low pathogen DNA recovery from available primary specimens or unculturable samples. A cost-effective hybrid capture assay for

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Weeber et al. (2024) studied this question.

synapsesocial.com/papers/68e7318bb6db6435876aad4f https://doi.org/10.1128/jcm.01305-23

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