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March 20, 2024Radiotherapy and OncologyOpen Access

Organs-at-risk dose and normal tissue complication probability with dynamic trajectory radiotherapy (DTRT) for head and neck cancer

Jenny Bertholet Paul‐Henry Mackeprang Hannes A. Loebner Silvan Mueller Gian Guyer Daniel Frei W. Volken Olgun Eliçin Daniel M. Aebersold Michael K. Fix Peter Manser

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Abstract

We compared dynamic trajectory radiotherapy (DTRT) to state-of-the-art volumetric modulated arc therapy (VMAT) for 46 head and neck cancer cases. DTRT had lower dose to salivary glands and swallowing structure, resulting in lower predicted xerostomia and dysphagia compared to VMAT. DTRT is deliverable on C-arm linacs with high dosimetric accuracy.

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Bertholet et al. (2024) studied this question.

synapsesocial.com/papers/68e732bfb6db6435876abdbd https://doi.org/10.1016/j.radonc.2024.110237

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A dosimetrically motivated pathﬁnding approach for non-isocentric dynamic trajectory radiotherapy2024 · 3 citations
2Comparative Dosimetric Analysis of conventional 3DCRT and VMAT for Head and Neck Cancer2024 · 2 citations
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4Impact of daily adaptive head and neck radiotherapy on toxicity and quality-of-life: results of the DARTBOARD phase II randomized trial2025 · 9 citations
5First clinical implementation of dynamic tumor-tracking volumetric modulated arc therapy with a gimbal-mounted linac: short delivery time and high precision.Original Research · 2026

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