Endoscopic submucosal dissection for treatment of esophageal leukoplakia reveals hidden histopathology

A 59-year-old woman with a medical history of severe reflux esophagitis, chronic obstructive pulmonary disease, and tobacco and alcohol dependence was referred to our clinic for an assessment of progressive hyperkeratotic lesions in the mid-section of the esophagus, which were incidentally found on routine endoscopic surveillance. Prior to the initial presentation at our clinic, the patient had undergone endoscopic monitoring for a duration of 2.5 years. With the exception of sporadically occurring reflux symptoms, the patient remained asymptomatic. There was no indication of B-symptoms.