IsoDMT analogs with heterocyclic substitutions at the indole C(3) were prepared in a hydrogen-autotransfer (HA) alkylation and tested in combination with natural and unnatural clavine alkaloids in a model of light-induced retinal degeneration for protection against retinal degeneration. As assessed with OCT and ERG, three compounds showed better efficacy than positive-control bromocriptine at equivalent systemically administered doses. These studies provide further insight into the role that 5-HT receptors play in ocular diseases.
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Pazur et al. (2024) studied this question.
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