March 20, 2024Open Access

FIGURE 5 from Autophagy Inhibition–induced Cytosolic DNA Sensing Combined with Differentiation Therapy Induces Irreversible Myeloid Differentiation in Leukemia Cells

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Combined ATRA and MRT treatment retards acute myeloid leukemia progression in vivo, reducing blast cell counts and prolonging survival in leukemia-bearing mice.
Mice receiving combined therapy show significant reductions in peripheral blood GFP+ leukemia cells and lower c-kit+ blast cell frequencies across bone marrow (P < 0.01, n = 8).
Experimental in vivo evaluation assessed survival, white blood cell counts, and myeloid differentiation across spleen and bone marrow; mouse model, further preclinical work needed.

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Implication

Animal study reveals combined ATRA and MRT retard acute myeloid leukemia progression in mice, highlighting therapeutic potential of autophagy inhibition.

Cite This Study

Baba et al. (2024) studied this question.

synapsesocial.com/papers/68e733bdb6db6435876ad380 https://doi.org/10.1158/2767-9764.25444124.v1

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Implication

Animal study reveals combined ATRA and MRT retard acute myeloid leukemia progression in mice, highlighting therapeutic potential of autophagy inhibition.

FIGURE 5 from Autophagy Inhibition–induced Cytosolic DNA Sensing Combined with Differentiation Therapy Induces Irreversible Myeloid Differentiation in Leukemia Cells

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Implication

Cite This Study

FIGURE 5 from Autophagy Inhibition–induced Cytosolic DNA Sensing Combined with Differentiation Therapy Induces Irreversible Myeloid Differentiation in Leukemia Cells

Key Points

Discussion

Implication

Cite This Study

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