March 19, 2024Nature MicrobiologyOpen Access

Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition

View Full Paper

Ask AI

Bookmark

Authors

HCHao-Wei ChangWashington University in St. Louis ELEvan M. LeeWashington University in St. Louis WWWilliam Yi WangNorthwestern Polytechnical University

Discussion

Member takes

Implication

Randomized trial reveals improved weight gain from microbiota-directed food via Prevotella copri in malnourished children, highlighting targeted bacterial pathways.

Key Points

Ponderal growth improves significantly when the therapeutic food MDCF-2 stimulates glycan utilization pathways expressed by resident Prevotella copri strains.
Gnotobiotic mice colonized with defined consortia showed that Prevotella copri interacts with Bifidobacterium infantis to modulate epithelial energy metabolism.
These findings support targeted MDCF-2 interventions to repair gut communities; however, preclinical mouse model mechanisms require further clinical validation.

Cite This Study

Chang et al. (2024) studied this question.

synapsesocial.com/papers/68e734edb6db6435876ae2bf https://doi.org/10.1038/s41564-024-01628-7

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial reveals improved weight gain from microbiota-directed food via Prevotella copri in malnourished children, highlighting targeted bacterial pathways.

Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition

Discussion

Member takes

Implication

Key Points

Cite This Study

Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider