March 19, 2024Breast Cancer ResearchOpen Access

TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9

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Authors

RHRan HuAnhui University of Traditional Chinese Medicine YCYu CaoGuiyang Medical University YWYuanyuan WangJinzhou Medical University

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Implication

Bioinformatics and immunohistochemistry assays show TMEM120B promotes stemness and drug resistance in breast cancer cells, highlighting a therapeutic target.

Key Points

TMEM120B-mediated stabilization of MYH9 strengthens breast cancer stem cells expansion, and this focal adhesions interaction accelerates chemotherapy resistance.
Miller/Payne grades 1–2 showed significantly higher TMEM120B levels than grades 3–5, correlating with advanced TNM stage and docetaxel chemotherapy resistance.
Immunoprecipitation assays and mouse xenograft model analysis demonstrated that TMEM120B binds MYH9 directly, preventing CUL9-mediated degradation in cells.
Highlights TMEM120B inhibition as a strategy to counter chemotherapy resistance—mouse model; further preclinical work needed before clinical translation.

Cite This Study

Hu et al. (2024) studied this question.

synapsesocial.com/papers/68e734edb6db6435876ae409 https://doi.org/10.1186/s13058-024-01802-z

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Implication

Bioinformatics and immunohistochemistry assays show TMEM120B promotes stemness and drug resistance in breast cancer cells, highlighting a therapeutic target.

TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9

Discussion

Member takes

Implication

Key Points

Cite This Study

TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9

Discussion

Member takes

Implication

Key Points

Cite This Study

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