Patterns and profiles of drug resistance-conferring mutations in Mycobacterium tuberculosis genotypes isolated from tuberculosis-suspected attendees of spiritual holy water sites in Northwest Ethiopia
Cross-sectional study reveals frequent katG and rpoB mutations in tuberculosis isolates from holy water site attendees, highlighting predominant SIT149 and SIT21 sublineages.
Key Points
Resistance mutations to isoniazid and rifampicin occurred in 16.4% and 12.3% of isolates, driven primarily by katG and rpoB gene alterations.
Cross-sectional study of 122 Mycobacterium tuberculosis isolates evaluated first-line resistance profiles using line probe assays and spoligotyping.
Highlights SIT149 and SIT21 sublineages among rifampicin and isoniazid resistant strains, calling for expanded genomic sequencing to monitor evolving transmission.