March 19, 2024Organic Letters

Palladium-Catalyzed Dehydrogenative Carbonylative Esterification of Allenoic Acids for the Synthesis of γ-Butyrolactone Derivatives

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Authors

BWBolin WangJiangsu University MRMingzhe RenUniversity of Copenhagen NINasır IqbalXi'an Jiaotong University

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Implication

Experimental study demonstrates efficient palladium-catalyzed esterification of allenoic acids into γ-butyrolactones, highlighting practical utility for bioactive molecule synthesis.

Key Points

Dehydrogenative carbonylative esterification of allenoic acids yields diverse esterified γ-butyrolactone derivatives under mild palladium catalysis.
A heterogeneous catalyst known as Pd-AmP-MCF enabled the transformation under biomimetic aerobic oxidation across over 50 synthetic examples.
Facile assembly of functionalized γ-butyrolactone products supports broad applications in the sustainable synthesis of complex bioactive compounds.

Cite This Study

Wang et al. (2024) studied this question.

synapsesocial.com/papers/68e73502b6db6435876aebd3 https://doi.org/10.1021/acs.orglett.4c00572

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Implication

Experimental study demonstrates efficient palladium-catalyzed esterification of allenoic acids into γ-butyrolactones, highlighting practical utility for bioactive molecule synthesis.

Palladium-Catalyzed Dehydrogenative Carbonylative Esterification of Allenoic Acids for the Synthesis of γ-Butyrolactone Derivatives

Discussion

Member takes

Implication

Key Points

Cite This Study

Palladium-Catalyzed Dehydrogenative Carbonylative Esterification of Allenoic Acids for the Synthesis of γ-Butyrolactone Derivatives

Discussion

Member takes

Implication

Key Points

Cite This Study

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