Enantioselective Ring-Closing Aminomethylamination of Allylic Aminodienes with Aminals Triggered by C–N Bond Metathesis

A conceptually novel strategy utilizing a cyclopalladated complex as an electrophile to activate the C–N bond for the C–N bond metathesis between allylamines and aminals is developed, which enables an efficient ring-closing aminomethylamination of allylic aminodienes and aminals. The reaction proceeds under mild reaction conditions and displays a remarkable scope. Utilizing a modified Trost-type diphosphine as the ligand, this method enables the efficient synthesis of 5–10-membered aminoallylated chiral N-heterocycles in good yields with high enantiomeric excess values.