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Fluorescence imaging has been widely used in fields like (pre)clinical imaging, as well as in other domains. With advancements in imaging technology and the development of new fluorescent labels, fluorescence lifetime imaging is gradually gaining recognition. Our research department is developing the CAPS camera, based on the Current-Assisted Photonic Sampler, to achieve real-time fluorescence lifetime imaging in the NIR (700-900nm) region. Incorporating fluorescence lifetime into endoscopy would further differentiate malignant and benign cells based on their distinct lifetimes. Therefore, the capabilities of the system are demonstrated using a rigid endoscope involving various phantoms and various lifetime processing approaches to get the uniform lifetime image because of the independence of fluorescence lifetime to the intensity when the intensity image is not.
Iranian et al. (Tue,) studied this question.