Abstract P532: Association of Subclinical Atherosclerosis With Cardiac Structure and Function in the Rural Cohort Study

Introduction: Rural communities may have disproportionate cardiovascular disease (CVD) morbidity and mortality, but few data examine relations of subclinical atherosclerosis with cardiac structure and function in Southern rural areas. Hypotheses: We hypothesized that subclinical atherosclerosis will be associated with adverse cardiac remodeling. Methods: Participants with non-contrast cardiac computed tomography (CT) and artificial intelligence-guided echocardiography (AI echo) in the Alabama subcohort of the Risk Underlying Rural Areas Longitudinal (RURAL) study were included (N=942, median age 51, 70% women, 80% Black). CAC associations with AI echo measures were examined, adjusting for age, sex, and self-reported race/ethnicity. Results: Table 1 shows descriptive statistics for AI echo measurements. Table 2 shows CAC score >100 had higher LV mass and lower LVEF compared to those below this threshold in adjusted analyses. LA volume and GLS were not associated with CAC in adjusted analyses. Conclusion: Subclinical atherosclerosis associated with adverse cardiac remodeling cross-sectionally in our Southern rural sample.