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March 18, 2024Journal of the American Heart AssociationOpen Access

Impaired Relaxation in Induced Pluripotent Stem Cell‐Derived Cardiomyocytes with Pathogenic TNNI3 Mutation of Pediatric Restrictive Cardiomyopathy

Renjie Wang Moyu Hasegawa Hidehiro Suginobe Chika Yoshihara Yoichiro Ishii Atsuko Ueyama Kazutoshi Ueda Kazuhisa Hashimoto Masaki Hirose Ryo Ishii Jun Narita Takuji Watanabe Takuji Kawamura Masaki Taira Takayoshi Ueno Shigeru Miyagawa Hidekazu Ishida

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Abstract

Restrictive cardiomyopathy (RCM) is characterized by impaired diastolic function with preserved ventricular contraction. Several pathogenic variants in sarcomere genes, including

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Wang et al. (2024) studied this question.

synapsesocial.com/papers/68e7387fb6db6435876b16af https://doi.org/10.1161/jaha.123.032375

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