Innentitelbild: Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity (Angew. Chem. 14/2024)

Distinguish good from evil by selective endosomal escape. The nuanced endo/lysosomal activity of cathepsin B across cell types can act as a stimulus for cell-specific endosomal escape of proteins before degradation. In their Research Article (e202317817), Kazunori Kataoka, Horacio Cabral, et al. report nanocarriers leveraging on this differentiated cathepsin B activity to achieve cancer cell-specific delivery of antibodies. This innovative approach offers a new means for targeted intracellular delivery.