Rücktitelbild: Bioinspired Selenium‐Nitrogen Exchange (SeNEx) Click Chemistry Suitable for Nanomole‐Scale Medicinal Chemistry and Bioconjugation (Angew. Chem. 15/2024)

Selenium–nitrogen exchange (SeNEx) chemistry creates seleno-connecting linkage to efficiently explore the organo-Se chemical world. In their Research Article (e202318534), Wei Hou, Hongtao Xu et al. put forward the concept of SeNEx chemistry based on the excellent performance of the reaction between benzoselenazolones and terminal alkynes. This reaction exhibits modularity, robustness, mild reaction conditions, and fast kinetics, and can be used in nanomole-scale parallel synthesis, DNA-encoded library synthesis, and peptide and protein bioconjugation.