March 18, 2024Open Forum Infectious DiseasesOpen Access

Dolutegravir/Lamivudine Is Noninferior to Continuing Dolutegravir- and Non-Dolutegravir-Based Triple-Drug Antiretroviral Therapy in Virologically Suppressed People With Human Immunodeficiency Virus: DUALING Prospective Nationwide Matched Cohort Study

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Dolutegravir/lamivudine maintenance is noninferior to continuing triple-drug antiretroviral therapy, preserving virological suppression at one year.
Treatment failure occurred in 8.72% of dolutegravir-based cases versus 12.50% of controls by intention-to-treat analysis, meeting noninferiority criteria.
Prospective cohort study across twenty-four HIV treatment centers matched cases to controls, supporting dolutegravir/lamivudine maintenance in routine care.

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Implication

Randomized noninferiority trial demonstrates noninferior efficacy of dolutegravir/lamivudine to triple therapy in suppressed HIV, supporting two-drug maintenance in routine clinical practice.

Cite This Study

Vasylyev et al. (2024) studied this question.

synapsesocial.com/papers/68e73996b6db6435876b352c https://doi.org/10.1093/ofid/ofae160

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Implication

Randomized noninferiority trial demonstrates noninferior efficacy of dolutegravir/lamivudine to triple therapy in suppressed HIV, supporting two-drug maintenance in routine clinical practice.

Dolutegravir/Lamivudine Is Noninferior to Continuing Dolutegravir- and Non-Dolutegravir-Based Triple-Drug Antiretroviral Therapy in Virologically Suppressed People With Human Immunodeficiency Virus: DUALING Prospective Nationwide Matched Cohort Study

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Discussion

Implication

Cite This Study

Dolutegravir/Lamivudine Is Noninferior to Continuing Dolutegravir- and Non-Dolutegravir-Based Triple-Drug Antiretroviral Therapy in Virologically Suppressed People With Human Immunodeficiency Virus: DUALING Prospective Nationwide Matched Cohort Study

Key Points

Discussion

Implication

Cite This Study

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