FIGURE 1 from Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression

KYN enrichment in ovarian cancer patient ascites with high IL6. A, IL6 cytokine ELISA to stratify patients with HGSC-associated ascites. Red dots = IL6 “high” and blue dots = IL6 “low.” B, Global untargeted metabolomics analysis is shown from 10 patients with IL6-high and 10 with IL6-low ascites samples (P < 0.05). C, KYN levels in IL6-high and -low ascites samples with unpaired t test. Error bars, SEM. D, TRP catabolism pathway.