Evaluates SOX10 and RET expression in Hirschsprung disease, indicating their role in pathogenesis.
Key Points
Aberrant SOX10 and RET expression were found in Hirschsprung disease patients, suggesting their significant involvement.
SOX10 expression was upregulated in ganglionic and aganglionic colons of patients, with fold changes of 2.84 and 3.72, respectively.
RET expression showed significant downregulation, with reductions of 11.71-fold and 29.96-fold in ganglionic and aganglionic colons, respectively, compared to controls' colons early on. This analysis utilized quantitative real-time polymerase chain reaction to evaluate tissue samples between groups.