New Analogues of Amides and Quinolinones Produced by Streptomyces sp. YIM S01983

Streptomide ( 1 ), a new amide analogue, streptomynone ( 2 ), a new quinolinone, and ten known compounds including three aliphatic acids ( 3 ‐ 5 ), two amides ( 6 ‐ 7 ), four cyclic dipeptides ( 8 ‐ 11 ), and an adenosine ( 12 ) were isolated from the fermentation broth of Streptomyces sp. YIM S01983 isolated from a sediment sample collected in Bendong Village, Huadong Town, Chuxiong, China. Their structures were determined by analysis of the 1D/2D‐NMR and HR‐ESI‐MS spectra. Compound 12 presented weak antimicrobial activities against Candida albicans and Aligenes faecalis (MIC=64 μ g/mL). Compounds 7 and 12 showed weak cytotoxic activity against MHCC97H.