Angiogenic and vasoactive proteins in the maternal-fetal interface in healthy pregnancies and preeclampsia

Tweetable statement"Fetal EDN1 and sFLT1 were elevated in early onset preeclampsia and may mediate harmful effects to the offspring.We observed alterations in maternal levels of angiogenic and vasoactive proteins, including increasing abundance of EDN1 and sFLT1 from healthy, to late-onset preeclampsia and to early-onset preeclampsia."Short title: Angiogenic and vasoactive proteins in the maternal and fetal circulation in preeclampsia AJOG at a Glance:A. Why was this study conducted?Angiogenic and vasoactive proteins are players in preeclampsia.Knowledge of alterations in these proteins in maternal and fetal vessels, placental protein release, and maternal vs fetal abundance is important for understanding of the pathophysiology, mechanisms for late effects and for the development of novel treatments. B. What are the key findings?• Maternal angiogenic and vasoactive proteins show alterations in preeclampsia, including increasing abundance of sFLT1 and EDN1 from healthy, to late onset preeclampsia and to early onset preeclampsia.• Maternal sFLT1 and EDN1 showed a moderate to strong positive correlation.• Fetal EDN1 and sFLT1 were higher in early onset preeclampsia, whereas sENG and EDN3 were lower in both early and late onset preeclampsia, compared to healthy pregnancies.