March 15, 2024PeptidesOpen Access

MicroRNA regulation of islet and enteroendocrine peptides: Physiology and therapeutic implications for type 2 diabetes

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Dysregulation of specific micrornas disrupts glucoregulatory hormones in human pancreatic islets, impairing compensatory beta-cell responses in type 2 diabetes.
Review of human islet studies evaluates differential expression of micrornas, detailing their selective control over enteroendocrine peptides and incretin hormones.
Highlights the therapeutic potential of targeting micrornas to restore peptide secretion, offering viable intervention strategies for type 2 diabetes management.

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Review reveals microRNA dysregulation across islet and incretin pathways in type 2 diabetes, highlighting novel therapeutic targets.

Carr et al. (2024) studied this question.

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