Observational analysis reveals elevated MSDC-Mac to CD8 T cell ratios correlate with worse prognosis in Merkel cell carcinoma, highlighting myeloid-driven resistance to PD-1 pathway blockade.
Higher levels of MSDC-Mac cells relative to CD8 T cells in MCC tumors, and especially in tumors with high CD8 T cells infiltration, are associated with worse prognosis.
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Tabachnick‐Cherny et al. (2024) studied this question.
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