Isotretinoin therapy remains the therapeutic resort when all other treatments for acne have failed, however it is accompanied by a high side-effect profile. Isotretinoin-induced muscle injuries have been associated with markedly elevated creatine kinase (CK) in multiple reports in the literature. We report the case of a 36 year-old female on isotretinoin therapy for intractable acne who developed generalized myalgia one day subsequent to a strenuous workout at the gym.
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Awadhalla et al. (2024) studied this question.
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